Ming Guo, M.D., Ph.D University of California - Los Angeles | | Identifying Regulators of APP gamma-secretase
2003 New Initiatives Award in Aging
A key event in the genesis of Alzheimer's disease (AD) is the deposition of senile plaques consisting largely of a peptide known as beta-amyloid (Abeta) that is derived from the amyloid precursor protein (APP). A proteolytic activity called gamma-secretase cleaves APP in the transmembrane domain and is required for Abeta generation. Aberrant... (more) |