 | Ernesto Abel-Santos, Ph.D.
Albert Einstein College of Medicine of Yeshiva University | | Peptide Modulators of Bacterial Cell Differentiation
2002 New Scholar Award in Global Infectious Disease
The continuous threats of bioterrorism, combined with the appearance of multi-drug resistant infections, have created the need for the development of new antimicrobial treatments. Peptides have been used successfully to treat diseases ranging from cancer to infections, but their use has been limited by instability towards cellular catabolism.... (more) |
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 | Christopher F. Basler, Ph.D.
Mount Sinai School of Medicine | | Emerging Viruses: Interferon-Antagonists and Virulence
2002 New Scholar Award in Global Infectious Disease
Viruses have evolved ways to counteract the host innate immune response. Of particular importance are viral products which inhibit the antiviral activity of the type I interferon system. Such “interferon-antagonists” are essential for the virulence of several “model” viruses including influenza virus, Sendai virus, vaccinia virus and herpes... (more) |
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 | Kirk W. Deitsch, Ph.D.
Weill Medical College of Cornell University | | DNA Replication and var gene expression in Plasmodium falciparum
2002 New Scholar Award in Global Infectious Disease
Malaria continues to be a disease of extreme importance in the developing world, infecting 300-500 million people yearly and resulting in 1-2 million deaths, primarily of young African children. The vast majority of malaria morbidity and mortality is caused by infection with the mosquito borne protozoan parasite Plasmodium... (more) |
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Michael S. Diamond, M.D., Ph.D.
Washington University School of Medicine | | The Immunology and Neurobiology of West Nile Encephalitis in a Mouse Model of Disease
2002 New Scholar Award in Global Infectious Disease
The research in our laboratory focuses on the interface between viral infection and the host immune response. Two globally important mosquito-borne human pathogens are studied, the West Nile encephalitis and dengue hemorrhagic fever viruses.
Studies with West Nile virus virus (WNV) focus on understanding the... (more) |
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 | Michael S. Glickman, M.D.
Memorial Sloan Kettering Cancer Center | | Coordinate regulation of M. tuberculosis cell envelope composition during symbiosis
2002 New Scholar Award in Global Infectious Disease
Tuberculosis remains a major cause of mortality worldwide and new antimicrobials that would shorten TB chemotherapy are badly needed. Our laboratory studies the pathogenesis of infection with Mycobacterium tuberculosis (Mtb) through a multidisciplinary approach that includes bacterial genetics, lipid... (more) |
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 | Kristin M. Hager, Ph.D.
University of Notre Dame | | Analysis of membrane trafficking events in the regulation of organelle biogenesis and stability in Apicomplexan parasites
2002 New Scholar Award in Global Infectious Disease
Toxoplasma gondii is an opportunistic protozoan infecting one-third of world's population. Normally asymptomatic in immune-competent individuals, it induces severe pathology in children in utero and immune compromised individuals such as AIDS patients. The alarming spread... (more) |
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 | B. Joseph Hinnebusch, Ph.D.
National Institute of Allergy and Infectious Disease, National Institutes of
Health | | Mechanisms of Yersinia pestis transmission and pathogenicity
2002 New Scholar Award in Global Infectious Disease
Yersinia pestis, the cause of bubonic and pneumonic plague in humans, is transmitted primarily by fleas and has been responsible for devastating pandemics throughout history, including the Black Death of fourteenth century Europe. Plague reemerged in India and Africa during the 1990s and remains an international public health... (more) |
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 | Marc Lipsitch, D.Phil.
Harvard School of Public Health | | Antibiotic Resistance in Streptococcus pneumoniae: Transmission Dynamics and Consequences for Public Health
2002 New Scholar Award in Global Infectious Disease
Streptococcus pneumoniae is a leading cause of otitis media (middle ear infections), bacteremia (blood infection),
pneumonia, and meningitis in both developed and developing countries. Extensive use of antibiotics has led to
... (more) |
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 | David S. Schneider, Ph.D.
Stanford University School of Medicine | | Dissecting malaria vector-pathogen interactions using a Drosophila-Plasmodium genetic system
2002 New Scholar Award in Global Infectious Disease
Malaria is a disease that still infects hundreds of millions of people each year and kills more than a million. There is no useful vaccine and the parasite is becoming resistant to all available drugs. New methods are needed to combat this disease.
Our goal is to understand the factors in an... (more) |
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 | Fitnat Yildiz, Ph.D.
University of California - Santa Cruz | | Environmental factors that modulate biofilm formation dynamics in Vibrio cholerae O1 E1 Tor
2002 New Scholar Award in Global Infectious Disease
Alterations to aquatic environments via natural or anthropogenic factors can directly or indirectly lead to infectious disease outbreaks. At present, little information is available on the molecular ecology and evolutionary dynamics of infectious agents in the environment. Understanding environmental... (more) |
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