New Scholar Award in Aging
National Institute of Neurological Disorders and Stroke, National Institutes of Health
Life Extension of Drospohila by a Drug Treatment.
Aging is a common phenomenon shared by animals and plants, but our
understanding of why and how we age remains limited. It would be of great
biological interest and practical importance if we could gain insights into the
molecular basis of aging, learn to delay the aging process, and maintain the vigor
Model organisms amenable to genetic and molecular techniques, such as the
mouse, offer important advantages. However, much less laborious and
expensive are Drosophila, which have short generation time and can be rapidly
screened for mutations. My work is primarily being carried out using
Drosophila melanogaster as a model system.
A goal of my research is to advance our understanding of the genetic and
molecular mechanisms responsible for degenerative diseases and aging.
Specifically my goals are to identify genes that are involved in pathologies and
senescence. Finding key players in extension of lifespan will also contribute to
the prevention of premature aging syndromes such as Werner’s syndrome,
Down syndrome, and progeria or age-related diseases such as Alzheimer’s