The Rockefeller University
Inhibition of N-acetyltransferase.
Dr. Cole's research is devoted to evaluating the effects of melatonin on mammalian physiology. Melatonin is a hormone thought to be important in the regulation of circadian rhythm. It is taken as a medication by some travelers to prevent jet lag. Melatonin has even been speculated to be useful in preventing aging. A particular enzyme called serotonin N-acetyltransferase regulates melatonin production in animals and people. Dr. Cole is attempting to develop specific agents which block this enzyme and will therefore inhibit melatonin production. He will then evaluate the effects of such inhibitors on behavior and circadian function in animals. Such inhibitors will also be tested to see how they effect the aging process in animals