How cells die in Alzheimer's and other neurodegenerative diseases.
Fragments of Alzheimer's polypeptide (APP) are found in senile plaques. Some
fragments ( Ab, 1-40 and 1-42 ) appear to be toxic to the brain. Dr. Petsko
proposes to identify the enzyme (s) that produce these fragments and then, using
Ab, resistant mutants, determine how the Ab, peptides kill nerves.