Senior Scholar Award in Aging
Helen M. Blau, Ph.D.
Stanford University School of Medicine

Bone Marrow to Brain: Searching for markers of bone marrow stem cells with neurogenic potential

A challenge for the next decade will be to enhance the prospects for the increasing number of elderly afflicted with debilitating neurological diseases: Parkinson's or stroke. We recently discovered that adult bone marrow, transplanted into adult recipients, migrates to the brain and adopts neuronal characteristics. The goal of this proposal is to facilitate therapy by enriching for and enhancing differentiation of the requisite subset of bone marrow cells. This stem cell approach (adult marrow to adult brain) has particular advantages: the patient is his own donor, which overcomes problems such as the immune response, ethical issues, and access to cells.

Contact Dr. Blau.