Senior Scholar Award in Aging
Gregory A. Petsko, D. Phil.
Brandeis University

How cells die in Alzheimer's and other neurodegenerative diseases

Fragments of Alzheimer's polypeptide (APP) are found in senile plaques. Some fragments ( Ab, 1-40 and 1-42 ) appear to be toxic to the brain. Dr. Petsko proposes to identify the enzyme (s) that produce these fragments and then, using Ab, resistant mutants, determine how the Ab, peptides kill nerves.

Contact Dr. Petsko.