Select a year 2001 2002 2003    Select a researcher Ernesto Abel-Santos, Ph.D. Christopher F. Basler, Ph.D. Yasmine Belkaid, Ph.D. Keril J. Blight, Ph.D. Michael D. Burkart, Ph.D. Kirk W. Deitsch, Ph.D. Michael S. Diamond, M.D., Ph.D. Philip Ralph Dormitzer, M.D., Ph.D. David A. Fidock, Ph.D. Michael Gale Jr., Ph.D. Michael S. Glickman, M.D. Kristin M. Hager, Ph.D. Claudia Hase, Ph.D. Kent Hill, Ph.D. B. Joseph Hinnebusch, Ph.D. Marc Lipsitch, D.Phil. John D. McKinney, Ph.D. Eleftherios “Terry” Mylonakis, M.D., Ph.D. Karen M. Ottemann, Ph.D. Lalita Ramakrishnan, M.D., Ph.D. Pejman Rohani, Ph.D. Michael Jeffrey Root,, M.D., Ph.D. David S. Schneider, Ph.D. Anita Sil, M.D., Ph.D Joseph D. Smith, Ph.D. Ali A. Sultan, M.D., Ph.D. Jatin M. Vyas, M.D., Ph.D. Paula Watnick, M.D., Ph.D. Elizabeth Winzeler, Ph.D. Fitnat Yildiz, Ph.D. Select a project Genetic Determinants of Chloroquine Resistance in Plasmod...Analysis of membrane trafficking events in the regulation ...Antibiotic Resistance in Streptococcus pneumoniae: Transmi...Antigen Processing and Presentation in the Specialized Ent...Bacterial and Host Contributions to the Maintenance of the...Biosynthetic Inhibition of Small Molecule Virulence Factor...Characterization of the NS4B Protein in Hepatitis C VirusCoordinate regulation of M. tuberculosis cell envelope com...Dissecting malaria vector-pathogen interactions using a Dr...DNA Replication and var gene expression in Plasmodium falc...Emerging Viruses: Interferon-Antagonists and VirulenceEnvironmental factors that modulate biofilm formation dyna...Functional Analysis of the Plasmodium GenomeGenetic Analysis of TB Persistence: Identification of New ...Genome-wide Binding Analysis of the Plasmodium falciparum ...Helicobacter pylori: Proteins and Processes that Contribut...Identification of the Bioenergetics Sensor Affecting Virul...Latency, Reactivation and Immunity in Chronic Parasitic Di...Mechanism and Biology of Trypanosome cell motility: contri...Mechanisms of Hepatitis C Virus PersistenceMechanisms of Yersinia pestis transmission and pathogenicityMolecular Analysis of Detoxification of Nitric Oxide in Molecular Mechanisms of Plasmodium Sporozoite PathogenicityNovel Regulators of Biofilm Development by Vibrio choleraePeptide Modulators of Bacterial Cell DifferentiationStructure-based Approach to Rotavirus Vaccine Design and C...Targeting Viral Entry Using the 5-Helix Protein Design Str...The Ecology and Evolution of Disease InterferenceThe Immunology and Neurobiology of West Nile Encephalitis ...Use of the Caenorhabditis elegans model of fungal p... Select an institution Albert Einstein College of Medicine of Yeshiva University Children's Hospital, Boston Harvard School of Public Health Massachusetts General Hospital Memorial Sloan Kettering Cancer Center Mount Sinai School of Medicine National Institute of Allergy and Infectious Disease, National Institutes of Health Oregon State University Rockefeller University Scripps Research Institute Seattle Biomedical Research Institute Stanford University School of Medicine Thomas Jefferson University Tufts University School of Medicine University of California - Los Angeles University of California - San Diego University of California - San Francisco University of California - Santa Cruz University of Cincinnati College of Medicine University of Georgia Research Foundation, Inc. University of Notre Dame University of Texas Southwest Medical Center University of Washington School of Medicine Washington University Washington University School of Medicine Weill Medical College of Cornell University

Studies with West Nile virus virus (WNV) focus on understanding the pathogenesis of infection, the mechanism by which the immune system limits dissemination into the central nervous system, and the nature of cell injury in neurons. A mouse model of infection has been established to determine how viral infection transitions from extraneural sites to the brain. Genetic deficiencies in several immune system mediators have been identified that result in severe disease phenotypes. Finally, to determine the mechanisms of cell injury in the brain, a cell culture model of WNV infection has been established in primary neuronal cells.  

Studies with dengue virus (DV) have focused on identifying the host and viral factors that modulate the severity of an infection. Interferons (IFN) inhibit DV infection by blocking the translation of viral RNA that occurs prior to RNA replication. Mutant DV strains have now been isolated that are resistant to IFN. Site-specific substitutions are underway to define the region(s) that confer resistance to IFN and the inhibitory molecules in the IFN antiviral pathway that block viral infection.

Contact Dr. Diamond.