Stanley Falkow, Ph.D.
Stanford University School of Medicine

The Natural History of Typhoid Infection in Vietnam.

The goal of the research is to examine the differences in typhoid bacilli causing acute typhoid fever as compared to the bacteria isolated from chronic typhoid carriers in Vietnam. One further component of our proposed work will be to obtain peripheral blood from patients suffering from acute typhoid fever to determine if there is a distinct pattern of host cell statement in these individuals that correlates with clinical outcomes. These data can be profitably compared with in-vitro studies of bacterial interaction with cultured human activated monocytes-macrophage cell lines.

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