Massachusetts Institute of Technology
Exploration of the C.elegans insulin-like aging pathway.
Dr. Ruvkun has previously shown that an insulin-like signaling pathway regulates
longevity and metabolism in C. elegans. The most important output of this
pathway in C. elegans is the transcription factor DAF-16. Dr. Ruvkun now
proposes to search for the downstream targets of DAF-16 in order to identify the
downstream daf-16 genes involved in longevity control.