Senior Scholar Awards in Aging - 2004

Monica Driscoll,   Ph.D. Rutgers University Genetic Analyses of Extended Healthspan in C. elegans	Caleb E. Finch,   Ph.D. University of Southern California ApoE Isoforms in the Evolution of Human Diet and Longevity from Chimpanzee-like Ancestors	Alfred L. Goldberg,   Ph.D. Harvard Medical School Regulation of Protein Degradation by the Ubiquitin-Proteasome Pathway in Aging
Robert D. Goldman,   Ph.D. Northwestern University Nuclear Lamin A Mutations in Progeria	Harry B. Gray,   Ph.D. California Institute of Technology Misfolding and Aggregation of Alzheimer’s and Parkinson’s Polypeptides	H. Robert Horvitz,   Ph.D. Massachusetts Institute of Technology Genetic Control of Aging in C. elegans
Estela Medrano,   Ph.D. Baylor College of Medicine Epigentic Control of Senescence and Aging	Thomas A. Rando,   M.D., Ph.D. Stanford University Mechanisms of Rejuvenation of Tissue-specific Stem Cells	Heidi Scrable,   Ph.D. University of Virginia Genetic Models to Chart the Course of Aging in the Mouse
Marc Tatar,   Ph.D. Brown University Metabolomic Analysis of Drosophila Aging by Stable Isotope Spectrometry	Alexander Varshavsky,   Ph.D. California Institute of Technology Lifespan Extension: Overexpression Strategies in the Mouse and Yeast

Senior Scholar Awards in Global Infectious Disease - 2004

John Carlson,   Ph.D. Yale University Rational Development of Novel Insect Repellents and Traps for the Control of Disease Vectors	Karen P. Day,   Ph.D. New York University School of Medicine Quorum Sensing and Malaria Parasites	JoAnne L. Flynn,   Ph.D. University of Pittsburgh Host-mediated Control of Tuberculosis: What are the Important Factors?
Jorge Galan,   D.V.M., Ph.D. Yale University School of Medicine Molecular and Functional Bases of Campylobacter jejuni Pathogenesis	Alexander D. Johnson,   Ph.D. University of California - San Francisco Prions, Epigenetics, and Virulence in a Fungal Pathogen	Beth Levine,   M.D. University of Texas Southwestern Medical Center at Dallas Autophagy as a Novel Mechanism of Innate Immunity against Intracellular Pathogens
Ruslan Medzhitov,   Ph.D. Yale University School of Medicine Immunobiology of Co-infection	Megan B. Murray,   M.D. Harvard School of Public Health Comparative Genomics and the Molecular Epidemiology of Tuberculosis	Daniel A. Portnoy,   Ph.D. University of California - Berkeley Production of Muramyl Dipeptides and Induction of Type I Interferon by Listeria monocytogenes and Mycobacterium tuberculosis
Dyann Wirth,   Ph.D. Harvard School of Public Health Diversifying Selection in Plasmodium falciparum

New Scholar Awards in Aging - 2004

Michael H. Brodsky,   Ph.D. University of Massachusetts Medical School Epigenetic Regulation of Drosophila Telomere Protection	Andrew G. Dillin,   Ph.D. Salk Institute for Biological Studies Regulation of Aging by Insulin/IGF-1 and Mitochondrial Signaling Pathways	Eitan Glick,   Ph.D. University of Washington Age-dependent Defects in the Mitochondrial Import Machinery
Jaime Grutzendler,   M.D. Northwestern University Dynamics of Neuronal-Microglia Interactions in Alzheimer’s disease	Su-Ju Lin,   Ph.D. University of California - Davis Genetic and Chemical Genetic Approaches to Study the MolecularMmechanism of Caloric Restriction and Longevity Regulation	Carlos Lois,   M.D., Ph.D. Massachusetts Institute of Technology The Role of Adult Neurogenesis in the Brain of Adult Songbirds: A Transgenic Approach
Scott Pletcher,   Ph.D. Baylor College of Medicine The Role of Innate Immunity Signaling in Lifespan Extension via Dietary Restriction in Drosophila melanogaster	Pere Puigserver,   Ph.D. Johns Hopkins University Regulation of Glucose Homeostasis through PGC-1a and SIR2a	Catherine A. Wolkow,   Ph.D. National Institute on Aging, National Institutes of Health Tracing Pathways for Controlling Longevity by Insulin-like Signaling in the Nervous System
Xiaohua Wu,   Ph.D. Scripps Research Institute Understanding the Role of the Nbs1/Mre11/Rad50 Complex in the Maintenance of Genome Stability and the Prevention of Premature Aging

New Scholar Awards in Global Infectious Disease - 2004

Peter John Bradley,   Ph.D. University of California - Los Angeles Establishing an Intracellular Niche in Apicomplexan Parasites: The Role of Novel Rhoptry Proteins Conserved in Toxoplasma and Plasmodium	George Dimopoulos,   Ph.D. Johns Hopkins University Characterization of a Pattern Recognition Receptor Family in Anopheles gambiae: Implication of GNBPs in the Mosquito’s Molecular Defense Against Malaria	Danielle A. Garsin,   Ph.D. University of Texas Health Science Center - Houston C. elegans as a Model Host for Understanding the Genetics of Bacterial Infection
Stefan H. I. Kappe,   Ph.D. Seattle Biomedical Research Institute Gene expression and function in Plasmodium liver stages	Liming Li,   Ph.D. Northwestern University Facilitate Prion Research Using C. elegans	Mary X. D. O’Riordan,   Ph.D. University of Michigan Medical School Bacterial Regulation of Intracellular Immune Surveillance
Dirk Schnappinger,   Ph.D Cornell University Controlled Silencing of rpoB and ffh in M. smegmatis and M. tuberculosis	Neal Silverman,   Ph.D. University of Massachusetts Medical School Using Drosophila to Elucidate the Mechanisms of Pathogenesis: Genetic and Molecular Dissection of Signal Inhibition by Yersinia Virulence Factor YopJ	Marcelo Carlos Sousa,   Ph.D. University of Colorado - Boulder Detecting and Overcoming Antibiotic Resistance in Bacteria
Vanessa Sperandio,   Ph.D. University of Texas Southwestern Medical Center Cell-to-cell Signaling in E. coli O157:H7 Pathogenesis	Heather L. True-Krob,   Ph.D. Washington University Breaking barriers: Defining Environmental and Genetic Factors that Modulate the Barrier to Interspecies Transmission of Prions	Wolfgang Weninger,   M.D. Wistar Institute The Role of CD4+ Central Memory T Cells in Influenza Virus Immunity

Senior Scholar Awards in Aging - 2003

Frederick W. Alt,   Ph.D Center for Blood Research, Boston The Biology of Mammalian Sir2 Homologs and their Role in Lifespan Determination	Spyridon Artavanis-Tsakonas,   Ph.D. Massachusetts General Hospital Cancer Center A Novel Class of Aging Genes in Drosophila melanogaster	Andrzej Bartke,   Ph.D. Southern Illinois University School of Medicine Early Hormonal Signaling and Longevity: Role of Long-term Alterations in Glucose Homeostasis
Ronald A. DePinho,   M.D. Dana Farber Cancer Institute, Harvard Medical School The Genetic Role of Telomere Dynamics and DNA Damage Response in Stem Cell Depletion, Organ Homeostasis and Aging	Jeff W. Lichtman,   M.D., Ph.D. Harvard University Time Lapse Imaging of Neurons as They Age	Susan L. Lindquist,   Ph.D. Whitehead Institute for Biomedical Research Investigating the Potential Involvement of Cellular Quality Control Mechanisms and the Mammalian Prion, PrP, in Neurodegenerative Diseases
Olivia M. Pereira-Smith,   Ph.D. University of Texas Health Science Center - San Antonio The Role of the MORF/MRG Family of Novel Transcription Factors in In Vitro and In Vivo Aging	Fred E. Regnier,   Ph.D, co-PI Purdue University A Novel Proteomic Approach to Identifying, Sequencing, and Quantifying Oxidatively Damaged Proteins in Tissues of Aged Animals	Arlan G. Richardson,   Ph.D, co-PI University of Texas Health Science Center - San Antonio A Novel Proteomic Approach to Identifying, Sequencing, and Quantifying Oxidatively Damaged Proteins in Tissues of Aged Animals
Joshua R. Sanes,   Ph.D Harvard University Time Lapse Imaging of Neurons as They Age	James L. Sherley,   M.D., Ph.D. Massachusetts Institute of Technology Identification of Chemical “Age Spots” on Immortal DNA Strands in Adult Stem Cells	Eric Verdin,   M.D. J. David Gladstone Institutes Role of a SIRT3, a Sir2-related Mitochondrial Protein Deacetylase, in Aging
Robert A. Weinberg,   Ph.D. Whitehead Institute for Biomedical Research Cell Physiologic Stresses and Telomere-Based Cell Senescence

Senior Scholar Awards in Global Infectious Disease - 2003

Roy Curtiss, III,   Ph.D. Washington University Providing an Economic Benefit to Using a Vaccine to Enhance Food Safety and to Reduce Antibiotic Use in Agriculture	Richard A. Flavell,   Ph.D. Yale University School of Medicine Role of Nucleotide Binding Domain-Leucine Rich Repeat Proteins in Host Defense to Microbial Challenge	Jeffrey I Gordon,   M.D. Washington University School of Medicine A Gnotobiotic Zebrafish Model for Analyzing Symbiotic Host-bacterial Interactions in the Mammalian Gut
Daniel L. Hartl,   Ph.D. Harvard University Conditional Targeted Deletions in Plasmodium falciparum	Karla Kirkegaard,   Ph.D. Stanford University School of Medicine Systematic Analysis of Positive-strand RNA Viral Transmission Genetics	Carl Nathan,   M.D. Weill Medical College of Cornell University Genomic Approach to Improved Immunogenicity of M. tuberculosis
Peter Palese,   Ph.D. Mount Sinai School of Medicine Cellular Genes and Viruses: Who Wins The War?	Charles M. Rice,   Ph.D. Rockefeller University Towards Broad-spectrum Antivirals: Functional Screens for Nonessential and Antiviral Host Genes	Alexander Rich,   M.D. Massachusetts Institute of Technology Viral Pathogenic Mechanisms Involving Z-DNA Binding Proteins
Abigail A. Salyers,   Ph.D. University of Illinois - Urbana-Champaign Resistance Gene Flow in the Human Colonic Microflora	Ronald P. Taylor,   Ph.D. University of Virginia Investigation of Mechanisms Leading to Anemia at Low Parasite Burden in Children with Malaria This research is being conducted by Dr. Taylor in collaboration with Dr. Waitumbe from the Kenyan Medical Research Institute.	John Waitumbi,   D.V.M., Ph.D Investigation of Mechanisms Leading to Anemia at Low Parasite Burden in Children with Malaria This research is being conducted by Dr. Taylor in collaboration with Dr. Waitumbe from the Kenyan Medical Research Institute.

New Scholar Awards in Aging - 2003

Shawn Cameron Ahmed,   Ph.D. University of North Carolina - Chapel Hill Germline Immortality in C. elegans	Cindy X. Cai,   M.D., Ph.D. Tufts University School of Medicine Nuclear Ferritin May Protect Against Oxidative and Light-induced DNA Damage in Retinal Pigment Epithelial Cells	Vera Gorbunova,   Ph.D. University of Rochester Effect of Aging on Efficiency and Accuracy of DNA Double-Strand Break Repair
Shin-ichiro Imai,   M.D., Ph.D. Washington University School of Medicine The Function of Mammalian NAD-dependent deacetylase Sir2a and NAD Biosynthesis Enzymes in Aging-associated Epigenetic Gene Regulation	Shuji Kishi,   M.D., Ph.D. Dana Farber Cancer Institute, Harvard Medical School Genetic Approaches for Functional Aging in Zebrafish	Jiyan Ma,   Ph.D. Ohio State University The Pathogenic Mechanism of Prion Disease
Kathryn J. Moore,   Ph.D. Massachusetts General Hospital Genetic and Functional Analysis of CD36-signaling in Age-related Chronic Inflammatory Diseases	Tannishtha Reya,   Ph.D. Duke University Medical Center Control of stem cell self-renewal and regeneration	Stephen Robert Wicks,   Ph.D. Boston College Natural Sequence Variation in C. elegans: Impact on Lifespan and Aging

New Scholar Awards in Global Infectious Disease - 2003

Yasmine Belkaid,   Ph.D. University of Cincinnati College of Medicine Latency, Reactivation and Immunity in Chronic Parasitic Disease	Keril J. Blight,   Ph.D. Washington University Characterization of the NS4B Protein in Hepatitis C Virus	Michael D. Burkart,   Ph.D. University of California - San Diego Biosynthetic Inhibition of Small Molecule Virulence Factors from Mycobacteria
Philip Ralph Dormitzer,   M.D., Ph.D. Children's Hospital, Boston Structure-based Approach to Rotavirus Vaccine Design and Cell Entry	Kent Hill,   Ph.D. University of California - Los Angeles Mechanism and Biology of Trypanosome cell motility: contribution to parasite development and disease pathogenesis	Eleftherios “Terry” Mylonakis,   M.D., Ph.D. Massachusetts General Hospital Use of the Caenorhabditis elegans model of fungal pathogenesis to identify virulence factors of the pathogenic yeast Cryptococcus neoformans
Pejman Rohani,   Ph.D. University of Georgia Research Foundation, Inc. The Ecology and Evolution of Disease Interference	Michael Jeffrey Root,,   M.D., Ph.D. Thomas Jefferson University Targeting Viral Entry Using the 5-Helix Protein Design Strategy	Anita Sil,   M.D., Ph.D University of California - San Francisco Molecular Analysis of Detoxification of Nitric Oxide in Histoplasma capsulatum
Ali A. Sultan,   M.D., Ph.D. Harvard School of Public Health Molecular Mechanisms of Plasmodium Sporozoite Pathogenicity

Senior Scholar Awards in Aging - 2002

Seymour Benzer,   Ph.D. California Institute of Technology Mitochondrial swirls, a link between oxidative stress and aging in Drosophila	Stanley N. Cohen,   M.D. Stanford University School of Medicine Genetic Mechanisms Regulating Replicative Aging in Diffierentiated Human Cell Populations	Art Gafni,   Ph.D. University of Michigan Single Molecule Studies of Age-Related Alterations in Heat Shock Factor 1
Cynthia J. Kenyon,   Ph.D. University of California - San Francisco Can the Heat-Shock Response Extend the Lifespan of the Mouse?	Stuart Kim,   Ph.D. Stanford University Medical Center Genomic approaches to studying aging in C. elegans	Gordon Lithgow,   Ph.D. Buck Institute for Age Research The Rapid Identification of Hormones and Pharmacological Compounds that Slow Aging in C. elegans
James F. Nelson,   Ph.D. University of Texas Health Science Center - San Antonio Rapid Screening for Longevity Mutants in Mice	Daniel Promislow,   Ph.D. University of Georgia Gene-gene interactions, gene networks and aging in natural population of Drosophila	Rudolph E. Tanzi,   Ph.D. Massachusetts General Hospital Role of the multiligand receptor, LRP. In Alzheimer’s disease-related neuropathogenesis: A model for age-related disorders involving LRP
Woodring E. Wright,   M.D., Ph.D. University of Texas Southwestern Medical Center Functional Tests of Replicative Aging in Organotypic Skin Equivalents

Senior Scholar Awards in Global Infectious Disease - 2002

Martin J. Blaser,   M.D. New York University School of Medicine Molecular definition of the bacterial population of human skin in health and disease	John C. Boothroyd,   Ph.D. Stanford University School of Medicine Evolution of Virulence in Eukaryotic Pathogens	Ronald W. Davis,   Ph.D. Stanford University School of Medicine Sexually Transmitted Disease Agents in the “Healthy” Human Vagina
Jack E. Dixon,   Ph.D. University of California - San Diego Bacterial Pathogen Families that Function in Both the Animal and Plant Kingdoms	Laurie H. Glimcher,   M.D. Harvard School of Public Health Arming the Immune System against Pathogens with Selective Biologics: The Next Generation of Vaccines	Roberto G. Kolter,   Ph.D. Harvard Medical School Ecological Influences on Pathogen Genome Evolution
Pradipsinh K. Rathod,   Ph.D. University of Washington Genomic tools to characterize hypermutating Plasmodium falciparum.	Lee W. Riley,   M.D. University of California - Berkeley Mycobacterium Tuberculosis Latency and Reactivation Tuberculosis	David S. Roos,   Ph.D. University of Pennsylvania Designing and Mining Pathogen Genome Databases: The Apicoplast as a Novel Drug Target in Plasmodium Parasites…and Other Stories
Gary K. Schoolnik,   M.D. Stanford University School of Medicine The Molecular Ecology of Vibrio cholerae in the Gangetic Delta—Whole genome expression profiles as ecosystem bioprobes

New Scholar Awards in Aging - 2002

Yidong Bai,   Ph.D. University of Texas Health Science Center - San Antonio Genetic and functional analysis of mitochondrial DNA mutations associated with aging.	Antonio Bedalov,   M.D., Ph.D. Fred Hutchinson Cancer Research Center Chemical Genetic Approaches to Aging	Ana Maria Cuervo,   M.D., Ph.D. Albert Einstein College of Medicine of Yeshiva University Restoration of chaperone-mediated autophagy activity in old rodents
Ya Ha,   Ph.D. Yale University School of Medicine Structural studies of human y-secretase	Michael Gordon Kaplitt,   M.D., Ph.D. Weill Medical College of Cornell University Effect of PTEN Anti-Oncogene on Age-Related Neurodegenerative Disorders	Tae-Wan Kim,   Ph.D. Columbia University Genetic Studies of Factors Controlling Amyloid Production
Steven Lyle,   M.D., Ph.D. Beth Israel Deaconess Medical Center, Harvard Medical School Molecular and Cell Biology of Adult Epithelial Stem Cells	Giovanni Paternostro,   M.D., Ph.D. Burnham Institute Genetic Analysis of Cardiac Aging in Drosophila	Jacob Raber,   Ph.D. Oregon Health & Science University Gender and Isoform-Specific Effects of ApoE on Cognition in Humans
Brad A. Rikke,   Ph.D. University of Colorado - Boulder QTLs Specifying the Retardation of Reproductive Senescence by Dietary Restriction

New Scholar Awards in Global Infectious Disease - 2002

Ernesto Abel-Santos,   Ph.D. Albert Einstein College of Medicine of Yeshiva University Peptide Modulators of Bacterial Cell Differentiation	Christopher F. Basler,   Ph.D. Mount Sinai School of Medicine Emerging Viruses: Interferon-Antagonists and Virulence	Kirk W. Deitsch,   Ph.D. Weill Medical College of Cornell University DNA Replication and var gene expression in Plasmodium falciparum
Michael S. Diamond,   M.D., Ph.D. Washington University School of Medicine The Immunology and Neurobiology of West Nile Encephalitis in a Mouse Model of Disease	Michael S. Glickman,   M.D. Memorial Sloan Kettering Cancer Center Coordinate regulation of M. tuberculosis cell envelope composition during symbiosis	Kristin M. Hager,   Ph.D. University of Notre Dame Analysis of membrane trafficking events in the regulation of organelle biogenesis and stability in Apicomplexan parasites
B. Joseph Hinnebusch,   Ph.D. National Institute of Allergy and Infectious Disease, National Institutes of Health Mechanisms of Yersinia pestis transmission and pathogenicity	Marc Lipsitch,   D.Phil. Harvard School of Public Health Antibiotic Resistance in Streptococcus pneumoniae: Transmission Dynamics and Consequences for Public Health	David S. Schneider,   Ph.D. Stanford University School of Medicine Dissecting malaria vector-pathogen interactions using a Drosophila-Plasmodium genetic system
Fitnat Yildiz,   Ph.D. University of California - Santa Cruz Environmental factors that modulate biofilm formation dynamics in Vibrio cholerae O1 E1 Tor

Senior Scholar Awards in Aging - 2001

Helen M. Blau,   Ph.D. Stanford University School of Medicine Bone Marrow to Brain: Searching for markers of bone marrow stem cells with neurogenic potential	Jochen Buck,   M.D., Ph.D. Weill Medical College of Cornell University Bicarbonate-activated adenylyl cyclase and aging	Catherine F. Clarke,   Ph.D., co-PI University of California - Los Angeles Intersection of two pathways in control of aging: nutritional coenzyme Q and DAF-2 signaling
Lawrence S.B. Goldstein,   Ph.D. University of California - San Diego, Howard Hughes Medical Institute Probing the role of axonal transport disturbance and transport-mediated signaling in Alzheimer’s Disease	Stephen Helfand,   M.D. University of Connecticut Health Center Genetic Dissection of Aging in Drosophila	Pamela L. Larsen,   Ph.D., co-PI University of Texas Health Science Center - San Antonio Intersection of two pathways in control of aging: nutritional coenzyme Q and DAF-2 signaling
Stuart Lipton,   M.D., Ph.D. Burnham Institute Use of Blood Stem Cells to Regenerate Neurons via the Transcription Factor hMEF2C	Victoria Lundblad,   Ph.D. Baylor College of Medicine Translating Yeast Telomere Biology to Human Cells: Identification of Activities that Regulate Human Telomere Maintenance and Cellular Proliferation	Mark Mayford,   Ph.D. Scripps Research Institute Mutagenic Screen for Longevity Genes in Mice
Simon Melov,   Ph.D. Buck Institute for Age Research Critically Testing the Free Radical Theory of Aging, and Development of a Practical Intervention	Fernando Nottebohm,   Ph.D. Rockefeller University Hypothesis to be tested: some aspects of functional aging result from reduced replacement in the adult CNS	John Tower,   Ph.D. University of Southern California Replicative Senescence of Drosophila Stem Cells in Vivo
Phyllis M. Wise,   Ph.D. University of California - Davis Estradiol is a Neuroprotective Factor in the Aging Brain: Mechanisms of Action

Senior Scholar Awards in Global Infectious Disease - 2001

Alan G. Barbour,   M.D. University of California - Irvine Transmission-blocking Vaccines Against Arthropod Vectors	William Bishai,   M.D., Ph.D. Johns Hopkins School of Public Health Transmission Blocking Vaccines for Tuberculosis	Jon Clardy,   Ph.D. Harvard Medical School New Antibiotics from Environmental DNA
Peter Cresswell,   Ph.D. Yale University School of Medicine Antiviral Effects of Interferon-Inducible Cytosolic Proteins	Stanley Falkow,   Ph.D. Stanford University School of Medicine The Natural History of Typhoid Infection in Vietnam	Gerald R. Fink,   Ph.D. Whitehead Institute for Biomedical Research The Role of Quorum Sensing in Fungal Disease
Lee Gehrke,   Ph.D. Massachusetts Institute of Technology Exploiting an Evolutionary Omission in Pathogenic RNA Viruses: Understanding the Advantages of BeingNon-polyadenylated	William R. Jacobs, Jr.,   Ph.D. Albert Einstein College of Medicine of Yeshiva University Development of Genetic Systems for Genetically Intractable Organisms	Keith A. Joiner,   M.D. University of Arizona Development of New Genetic Tools to Identify Nutrient Uptake Pathways in Malaria Parasites
W. Ian Lipkin,   M.D. Columbia University Pandora's Box Project	Richard M. Locksley,   M.D. University of California - San Francisco Optimizing Immunity to Complex Pathogens In Vivo	David A. Relman,   M.D. Stanford University School of Medicine, VA Palo Alto Health Care System The Human Intestinal Microbiome: Community Analysis, Host Response, and Role in Chronic Disease
Iwona Stroynowski,   Ph.D. University of Texas Southwest Medical Center Exploring Novel Pathways of Immune Defenses Against Orally Ingested Pathogens: Analysis of Nonclassical Class I MHC Antigens in Mouse Intestines

New Scholar Awards in Aging - 2001

Michael J. Bertram,   Ph.D. University of Alabama - Birmingham Genetic Analysis of the MORF4 Related Gene Family in Drosophila: Insights into Cellular Senescence	Sandy Chang,   M.D.,Ph.D M.D. Anderson Cancer Center Genomic Instability and Aging in Werner-Telomerase Compound Knockout Mice	Michael D. Ehlers,   M.D., Ph.D. Duke University Medical Center Molecular Mechanisms of Age-Related Changes at Hippocampal Synapses
Roman Giger,   Ph.D. University of Rochester Medical Center Mechanisms of Neural Plasticity in the Mammalian System	Yasunori Hayashi,   M.D., Ph.D. Massachusetts Institute of Technology Role of Neural Progenitors in Adult Hippocampal- and Olfactory Bulb-Dependent Learning and Memory	Kyung-Tai Min,   Ph.D. National Institute of Neurological Disorders and Stroke, National Institutes of Health Life Extension of Drospohila by a Drug Treatment
William A. Mohler,   Ph.D. University of Connecticut Health Center New Approaches to Characterizing Cellular Changes in Sarcopenia	Robert Sheaff,   Ph.D. University of Minnesota Cancer Center A Mechanistic Explanation for the Development of Neurodegenerative Diseases	David A. Sinclair,   Ph.D. Harvard Medical School Identification of Genes and Compounds that Extend Yeast Life Span
David G. Wells,   Ph.D. Yale University School of Medicine Synaptic Plasticity in the Aging Brain: Role of CPE-dependent Protein Synthesis

New Scholar Awards in Global Infectious Disease - 2001

David A. Fidock,   Ph.D. Albert Einstein College of Medicine of Yeshiva University Genetic Determinants of Chloroquine Resistance in Plasmodium falciparum Malaria	Michael Gale Jr.,   Ph.D. University of Texas Southwest Medical Center Mechanisms of Hepatitis C Virus Persistence	Claudia Hase,   Ph.D. Oregon State University Identification of the Bioenergetics Sensor Affecting Virulence Factor statement in Vibrio cholerae
John D. McKinney,   Ph.D. Rockefeller University Genetic Analysis of TB Persistence: Identification of New Drug Targets	Karen M. Ottemann,   Ph.D. University of California - Santa Cruz Helicobacter pylori: Proteins and Processes that Contribute to Persistent Infection	Lalita Ramakrishnan,   M.D., Ph.D. University of Washington School of Medicine Bacterial and Host Contributions to the Maintenance of the Granuloma in Tuberculosis Infections
Joseph D. Smith,   Ph.D. Seattle Biomedical Research Institute Genome-wide Binding Analysis of the Plasmodium falciparum Erythrocyte Membrane 1 Family of Cytoadherent Receptors	Jatin M. Vyas,   M.D., Ph.D. Massachusetts General Hospital Antigen Processing and Presentation in the Specialized Enterocyte, M Cell	Paula Watnick,   M.D., Ph.D. Tufts University School of Medicine Novel Regulators of Biofilm Development by Vibrio cholerae
Elizabeth Winzeler,   Ph.D. Scripps Research Institute Functional Analysis of the Plasmodium Genome

Senior Scholar Awards in Aging - 2000

Giuseppe Attardi,   M.D. California Institute of Technology Aging-dependent Large Accumulation of Mutations at Specific Sites in Human Mitochondrial DNA Control Region	Tamas Bartfai,   Ph. D. Scripps Research Institute Chronic Neuroprotection during Aging by UCP Mediated Simultaneous Reduction of Free Radical Formation and Exocitotoxicity	Nir Barzilai,   M.D. Albert Einstein College of Medicine of Yeshiva University Identification of Longevity Genes in Founder Populations
Roger Brent,   Ph. D. Molecular Sciences Institute Identification of Protein Regulators of Self-renewal, Differentiation, and Senescence in Embryonic Stem Cells	Linda B. Buck,   Ph. D. Fred Hutchinson Cancer Research Center A High Throughput Screen for Longevity Genes	Jack D. Griffith,   Ph. D. University of North Carolina - Chapel Hill Telomere Looping and Control of Cell Aging
Philip C. Hanawalt,   Ph. D. Stanford University School of Medicine Repair of Oxidative DNA Damage in Human Neurons	Peter J. Hornsby,   Ph. D. University of Texas Health Science Center - San Antonio Cell Transplantation Models for Gene Action in Human Aging	Thomas Kornberg,   Ph. D. University of California - San Francisco Toward a Comprehensive Assessment of Gene Expression during Development and Aging of Drosophila
Charles M. Lieber,   Ph. D. Harvard Medical School Molecular through Cellular Changes Responsible for Alzheimer's Disease	David Ron,   Ph. D. Skirball Institute - New York University School of Medicine Proteotoxicity and Aging	Thomas P. Sakmar,   M.D. Rockefeller University The Chromophore Regeneration Pathway in Age-related Macular Degeneration
Sangram S. Sisodia,   Ph. D. University of Chicago Molecular Determinants of Hippocampal Neuroplasticity in a Mouse Model of b-Amyloid Deposition

New Scholar Awards in Aging - 2000

Jay M. Edelberg,   Ph. D. Cornell University Regulation of Senescent Angiogenic Potential	Jeffrey S. Friedman,   Ph. D. Scripps Research Institute The Role of p66shc in Cellular Senescence and Mammalian Aging	Wen-Biao Gan,   Ph. D. Skirball Institute - New York University School of Medicine In Vivo Study of Age-related Changes in Synaptic Structure
Mike Hutton,   Ph. D. Mayo Clinic, Jacksonville In Vivo Analysis of the Role of Tau in Neurodegeneration.	David K. Orren,   Ph. D. University of Kentucky Chandler Medical Center Understanding the Role of Genomic Instability in Human Aging: The Paradigm of the Premature Aging Disease Werner Syndrome	Jeff J. Sekelsky,   Ph. D. University of North Carolina - Chapel Hill Functional Characterization of a Drosophila RecQ Helicase
Hong-Bing Shu,   Ph. D. National Jewish Medical Center Signaling by Tumor Necrosis Factor Family Members	James E. Sligh,   M.D., Ph. D. Vanderbilt University School of Medicine Altered Mitochondrial Function in Transgenic Models of Cutaneous Aging	Peiqing Sun,   Ph. D. Scripps Research Institute A Genetic Approach to Identification of Genes Involved in Cellular Senescence and Immortalization
Marc Tatar,   Ph.D. Brown University Neuroendocrine Regulation of Aging in Drosophila	Anthony D. Wagner,   Ph. D. Stanford University Age-related Changes in the Functional Neurobiology of Memory	Hui Zheng,   Ph. D. Baylor College of Medicine An Inducible Gene Knockout System for Alzheimer's Disease and Aging Research

Senior Scholar Awards in Aging - 1999

Bruce N. Ames,   Ph.D. Children's Hospital, Oakland Research Institute Reversal of Mitochondrial Decay: From Rats to Humans	Steven N. Austad,   Ph.D. University of Texas Health Science Center - San Antonio Genetic Mechanisms of Exceptional Oxidative Damage Resistance in Birds	James E. Cleaver,   Ph.D. University of California - San Francisco, UCSF Cancer Center Endogenous DNA Damage and Mechanisms of Aging
Gretchen J. Darlington,   Ph.D. Baylor College of Medicine Identification of Candidate Genes for Longevity in Long Lived Mouse Models	Titia de Lange,   M.D. , Ph.D. Rockefeller University The Role of T-loops in Aging of Human Cells	Michael E. Greenberg,   Ph.D. Children's Hospital, Boston The Role of P13K/Akt Dependent Phosphorylation of a Mammalian Fork Head Transcription Factor FKHRL1 in Cell Senescence and Organismal Aging
Lawrence A. Loeb,   M.D., Ph.D. University of Washington Aging in Mutator and Antimutator Mice	David S. Thaler,   Ph.D. Rockefeller University Mitochondrial Mutation and Aging	Douglas C. Wallace,   Ph.D. University of California - Irvine Mitochondrial Aging in the Chimpanzee
Sherman M. Weissman,   M.D. Yale University School of Medicine The Molecular/Physiological Basis for Accelerated Aging in the Werner's Syndrome

New Scholar Awards in Aging - 1999

Dominique Broccoli,   Ph.D. Fox Chase Cancer Center Molecular Mechanisms of Telomere Dependent Senescence	Phillip Carpenter,   Ph.D. University of Texas Medical School - Houston Biochemical Characterization of a Putative p53-binding Protein from Xenopus	Stewart Frankel,   Ph.D. Yale University School of Medicine The Regulation of Chromosomes and Longevity
Shiv L. S. Grewal,   Ph.D. Cold Spring Harbor Laboratory Heterochromatin Assembly and Replicative Life-Span in Fission Yeast	Danesh Moazed,   Ph.D. Harvard Medical School Connections Between the Nucleolus and Cellular Aging	Henry L. Paulson,   M.D., Ph.D. University of Iowa Mechanisms of Neuronal Dysfunction and Death in Neurodegenerative Proteinpathies
Zhou Songyang,   Ph.D. Baylor College of Medicine Functional Analysis of Aging and Cell Survival Signal Pathways in Mammalian Cells	David Q.H. Wang,   M.D., Ph.D. Beth Israel Deaconess Medical Center, Harvard Medical School Aging and Cholesterol Gallstone Formation: Molecular Mechanisms of Gallstone (Lith) Genes	Weidong Wang,   Ph.D. National Institute on Aging, National Institutes of Health Characterization of a Novel Protein Complex Involved in the Human Premature Aging Disease - Werner Syndrome
Huaxi Xu,   Ph.D. Burnham Institute Gonadal Steroid Regulation of ß-Amyloid Generation: Cellular Mechanisms and Animal Models

Senior Scholar Awards in Aging - 1998

Seymour Benzer,   Ph.D. California Institute of Technology Life extension genes in Drosophila	Judith Campisi,   Ph.D. Lawrence Berkeley National Laboratory Telomeres, Cell Phenotype and Aging	Luca Cavalli-Sforza,   M.D. Stanford University School of Medicine Genes Controlling Longevity in Centenarians
Stephen J. Elledge,   Ph.D. Baylor College of Medicine Connections Between the Telomere Sensing and DNA Damage Accumulation	Daniel E. Gottschling,   Ph.D. Fred Hutchinson Cancer Research Center Replicative senescence in S. cerevisia	Paul Greengard,   Ph.D. Rockefeller University Novel APP - containing synaptic organelles and Alzheimer's disease
Carol W. Greider,   Ph.D. Johns Hopkins University The roles of recombination and telomerase in telomere maintenance	Leonard Guarente,   Ph.D. Massachusetts Institute of Technology Molecular analysis of mammalian aging	Thomas E. Johnson,   Ph.D. University of Colorado - Boulder Identification of gerontogenes in the mouse
Cynthia J. Kenyon,   Ph.D. University of California - San Francisco Analysis of genes that control aging in C. elegans	Thomas Perls,   M.D., M.P.H Boston Medical Center Exploring the genetics of extreme longevity	Gregory A. Petsko,   D. Phil. Brandeis University How cells die in Alzheimer's and other neurodegenerative diseases
Gary Ruvkun,   Ph.D. Harvard Medical School Exploration of the C.elegans insulin-like aging pathway	Jerry W Shay,   Ph.D. University of Texas Southwest Medical Center Role of telomeres and telomerase in human aging

New Scholar Awards in Aging - 1998

Phillip A. Cole,   M.D., Ph.D Rockefeller University Inhibition of N-acetyltransferase	Todd Golde,   M.D., Ph.D Mayo Clinic, Jacksonville Presenilins and Gamma-Secretase Cleavage of the Amyloid Beta Protein Precursor	Francine Grodstein,   Sc.D. Brigham and Women's Hospital, Harvard Medical School Estrogen, Antioxidants, and Cognitive Function in Women
Bruce Hay,   Ph.D. California Institute of Technology Apoptosis	Elly Nedivi,   Ph.D. Massachusetts Institute of Technology CPG15, A Novel Growth Promoting Molecule Involved in Synaptic Plasticity	Hong Yan,   Ph.D. Brigham and Women's Hospital, Harvard Medical School Identification of Proteins Functionally Redundant to the Werner's Syndrome Gene Product