 | Steven N. Austad, Ph.D.
University of Texas Health Science Center - San Antonio | | Genetic Mechanisms of Exceptional Oxidative Damage Resistance in Birds
1999 Senior Scholar Award in Aging
Evidence that oxidative damage, a by-product of normal metabolism in virtually all animals, is causally involved in the process of aging and the development of degenerative disease has been steadily accumulating for more than forty years. An understanding of the exact nature of this damage to specific cell components and... (more) |
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 | Peter J. Hornsby, Ph. D.
University of Texas Health Science Center - San Antonio | | Cell Transplantation Models for Gene Action in Human Aging
2000 Senior Scholar Award in Aging
The overall aim of this grant is to provide new methods for the study of gene action in human aging, using cell transplantation techniques applied to human adrenocortical cells. Prior to beginning this grant, we had established methods for genetic modification of bovine adrenocortical cells and for examining the function of genetically... (more) |
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 | Catherine F. Clarke, Ph.D., co-PI
University of California - Los Angeles |
 | Pamela L. Larsen, Ph.D., co-PI
University of Texas Health Science Center - San Antonio | | Intersection of two pathways in control of aging: nutritional coenzyme Q and DAF-2 signaling
2001 Senior Scholar Award in Aging
The nematode Caenorhabditis elegans is an excellent model for genetic studies of the
aging process. Mutations in the clk-1 gene of C. elegans result in an extended life span,
slowed development and sluggish behavior. Our studies of the clk-1 mutants suggest that
the slowed rates of aging,... (more) |
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 | James F. Nelson, Ph.D.
University of Texas Health Science Center - San Antonio | | Gordon Research Conference on the Biology of Aging
2001 Conferences, Workshops & Education Award in Aging
The Ellison Medical Foundation awarded $10,000 to help support the Gordon Research Conference on the Biology of Aging: From Genetics to Physiology held at Queen's College in Oxford, England July 22-26, 2001. |
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| Steven N. Austad, Ph.D.
University of Texas Health Science Center - San Antonio | | 2001 Gerontological Society of America Annual Meeting
2001 Conferences, Workshops & Education Award in Aging
The Ellison Medical Foundation awarded $7,500 to help support the Scientific Symposia at the 2001 Gerontological Society of America Annual Meeting held November 15-18, 2001 in Chicago.
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Jan Vijg, Ph.D.
University of Texas Health Science Center - San Antonio | | Functional Genomics of Aging
2002 Conferences, Workshops & Education Award in Aging
The Ellison Medical Foundation awarded $10,000 to help fund the
Functional Genomics of Aging conference held in Seville, Spain April 24-27,
2002. This conference covered integrated genomic circuits that control
mechanisms of aging, survival, and stress responses. |
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Yidong Bai, Ph.D.
University of Texas Health Science Center - San Antonio | | Genetic and functional analysis of mitochondrial DNA mutations associated with aging.
2002 New Scholar Award in Aging
The overall goal of this study is to isolate mitochondrial DNA (mtDNA) mutations associated with aging, to analyze the accumulation of the mutations during aging and to determine the genetic and functional consequences of the age-dependent mtDNA mutations in mouse. In mammalian cells, over 90% of oxygen is... (more) |
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| James F. Nelson, Ph.D.
University of Texas Health Science Center - San Antonio | | Rapid Screening for Longevity Mutants in Mice
2002 Senior Scholar Award in Aging
Mutational screens in C. elegans and D. melanogaster demonstrate that single gene mutations can extend life span. The phenotypes associated with these mutations include reduced insulin and/or insulin-like growth factor signaling and increased resistance to oxidative and other life-threatening stressors. Mammalian models of extended life... (more) |
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 | Olivia M. Pereira-Smith, Ph.D.
University of Texas Health Science Center - San Antonio | | The Role of the MORF/MRG Family of Novel Transcription Factors in In Vitro and In Vivo Aging
2003 Senior Scholar Award in Aging
Normal cells grown in culture have a limited potential to divide and eventually become terminally non-dividing. This is called cell or replicative senescence and is used as a model to study aging at the cell level. Tumor-derived cells, in contrast, divide constantly without control. We have found that tumor... (more) |
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 | Fred E. Regnier, Ph.D, co-PI
Purdue University |
 | Arlan G. Richardson, Ph.D, co-PI
University of Texas Health Science Center - San Antonio | | A Novel Proteomic Approach to Identifying, Sequencing, and Quantifying Oxidatively Damaged Proteins in Tissues of Aged Animals
2003 Senior Scholar Award in Aging
One of the most widely accepted theories in aging research is the free radical or oxidative stress theory of aging, which states that a steady-state accumulation of oxidative damage in cells and tissues leads to aging. Over the past two decades, it has been shown that... (more) |
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| Steven N. Austad, Ph.D.
University of Texas Health Science Center - San Antonio |
 | Gary Ruvkun, Ph.D.
Harvard Medical School | | Molecular Biology of Aging Summer Course
2001 Summer Course Award in Aging
The Ellison Medical Foundation funded a three-week summer course on the Molecular Biology of Aging at the Marine Biological Laboratory, Woods Hole, MA for the years 2002 through 2004. The 2004 course, directed by Drs. Steven Austad and Gary Ruvkun, will be held August 2-21, 2004 at the Marine Biological Laboratory, Woods Hole, MA. Funds cover all expenses... (more) |
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| Olivia M. Pereira-Smith, Ph.D.
University of Texas Health Science Center - San Antonio | | The Gerontological Society of America Annual Meeting
2003 Conferences, Workshops & Education Award in Aging
The Ellison Medical Foundation awarded $10,351 to support symposia on Early Origins of Age-Related Disease and Protein Aggregation in Single, Double and Triple Neurodegenerative Brain Amyloidoses at the Gerontological Society of America Annual Meeting held San Diego, California on November 21-24, 2003. |
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Jan Vijg, Ph.D.
University of Texas Health Science Center - San Antonio | | Second International Conference on Functional Genomics of Aging
2004 Conferences, Workshops & Education Award in Aging
The Ellison Medical Foundation awarded $10,000 to help support the Second International Conference on Functional Genomics of Aging held in Hersonissos on Crete, Greece on April 28 – May 1, 2004.
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